Effect of chronic AICAR treatment on muscle fiber composition and enzyme activity in skeletal muscle of rats
نویسندگان
چکیده
Muscle fiber is the basic unit of skeletal muscle. types play a crucial role in improving meat quality. In current study, Wistar rats were chronic injected with 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) for four weeks order to define 5′-AMP-activated protein kinase (AMPK) activity on muscle composition, enzyme and mRNA expression type-related genes gastrocnemius (GS) Food intake body weight did not show significant difference after AICAR treatment (P > .05). The caused significantly increased number area proportion type I level MyHC < .05), succinic dehydrogenase (SDH) malate (MDH) activities but decrease IIB IIb IIx Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) .05) was glucose transporter 4 (GLUT-4) tended be higher = .052) group. These results demonstrated that AICRA induces oxidative switching, enhances GLUT4 level, mediated by PGC-1α.
منابع مشابه
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ژورنال
عنوان ژورنال: Journal of Applied Animal Research
سال: 2021
ISSN: ['0974-1844', '0971-2119']
DOI: https://doi.org/10.1080/09712119.2021.1889563